Neuropathology of mild cognitive impairment

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Mild Cognitive Impairment.

PURPOSE OF REVIEW As individuals age, the quality of cognitive function becomes an increasingly important topic. The concept of mild cognitive impairment (MCI) has evolved over the past 2 decades to represent a state of cognitive function between that seen in normal aging and dementia. As such, it is important for health care providers to be aware of the condition and place it in the appropriat...

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Mild Cognitive Impairment

Cognitive aging has positive and negative effects on mental abilities. With time and experience, we gain new knowledge and skills. We become wiser. However, for most adults cognitive aging also brings slower mental processing, reduced mental flexibility, increased susceptibility to distraction, and more difficulty learning new things. As an example, the amount of detail recalled from a short st...

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Mild Cognitive Impairment

It is estimated that up to one third of adults will experience a gradual decline in cognitive function known as mild cognitive impairment as they age (Low LF et al 2004; Busse A et al 2003). Less severe than dementia, mild cognitive impairment is defined as cognitive defects that do not interfere with daily living. It may include slower thinking, a reduced ability to learn, and impaired memory....

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Cholinergic plasticity in hippocampus of individuals with mild cognitive impairment: correlation with Alzheimer's neuropathology.

Several recent studies indicate that activity of cholinergic enzymes in the cortex of people with mild cognitive impairment (MCI) and early Alzheimer's disease (AD) are preserved. We correlated levels of hippocampal choline acetyltransferase (ChAT) activity with the extent of AD lesions in subjects from the Religious Order Study, including cases with no cognitive impairment (NCI), MCI, and with...

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Profile of Cognitive Complaints in Vascular Mild Cognitive Impairment and Mild Cognitive Impairment

Objective. Vascular mild cognitive impairment (VaMCI) is differentiated from mild cognitive impairment (MCI) by the presence of vascular events such as stroke or small vessel disease. Typically, MCI and VaMCI patients present with subjective complaints regarding cognition; however, little is known about the specific nature of these complaints. We aimed to create a profile of subjective cognitiv...

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ژورنال

عنوان ژورنال: Rinsho Shinkeigaku

سال: 2012

ISSN: 0009-918X,1882-0654

DOI: 10.5692/clinicalneurol.52.851